Institute of Chemistry of the Academy of Sciences of Moldova Larisa Postolachi chemjm_correspondence@yahoo.com mEDRA 20161225

07 10.19261/cjm.2016.11(1).07 http://www.cjm.asm.md/sites/default/files/article_files/ChemJMold201611(1)_55-60_Daoudi.pdf Institute of Chemistry of the Academy of Sciences of Moldova mEDRA 01 Institute of Chemistry of the Academy of Sciences of Moldova MD 07 1857-1727 JB 07 2345-1688 JD 11 1 June 2016 01 201606 7 11 55 60 6 1 A01 Sofiane Daoudi Daoudi, Sofiane Sofiane Daoudi 2 A01 Tahar Benaissa Benaissa, Tahar Tahar Benaissa 3 A01 Djallal Eddine Adli Adli, Djallal Eddine Djallal Eddine Adli 4 A01 Nisserine Hamini-Kadar Hamini-Kadar, Nisserine Nisserine Hamini-Kadar 01 eng 20 1,3,4-oxadiazole; quaternary ammonium compounds; DMAEMA; DEAEMA; antimicrobial activities 01 This study describes the synthesis of some novel compounds containing bis-1,3,4-oxadiazole bearing quaternary ammonium salt moieties. The newly synthesized compounds were evaluated for their antibacterial activity against various gram-positive and gram-negative strains of bacteria, and the antifungal activities were tested against three phytopathogenic fungi namely, Fusarium oxysporum, Fusarium commune and Fusarium rodelens. 201606 2016 Institute of Chemistry of the Academy of Sciences of Moldova 10.1016/j.imbio.2011.08.004 10.1016/S2221-1691(12)60115-4 10.1016/j.transproceed.2014.08.032 10.1016/j.jgar.2015.02.005 10.1016/j.bmc.2011.12.049 10.1016/j.ejphar.2006.08.025 10.1016/j.bmc.2015.02.056 10.4236/pp.2013.43A003 10.1016/j.carbpol.2009.01.020 Kavitha, S.; Gnanavel, S.; Kannan, K. Biological aspects of 1,3,4-oxadiazole derivatives. Asian Journal of Pharmaceutical and Clinical Research, 2014, 7(4), pp. 11-20 Musmade, D.S.; Pattan, S.R.; Manjunath, S.Y. Oxadiazole a nucleus with versatile biological behaviour. International Journal of Pharmaceutical Chemistry, 2015, 5(1), pp. 11-20 10.1016/j.ejmech.2014.04.045 Shivi, B.; Monika, G. 1,3,4-Oxadiazole as antimicrobial agents: An overview. Journal of Chemical and Pharmaceutical Research, 2011, 3(3), pp. 137-147 10.1007/s00044-010-9335-0 10.2174/138955711797655407 10.1016/j.bmcl.2015.03.001 10.1016/j.bmcl.2014.09.086 10.1016/j.cbi.2009.07.014 10.1038/clpt.1983.170 10.1016/j.bmc.2013.08.002 Somani, R.R.; Balkund, V.D.; Nikam, S.R.; Shirodkar, P.Y.; Zope, D.B. Synthesis, antibacterial and anti-tubercular evaluation of some 1,3,4-oxadiazole based Mannich bases. International Journal of ChemTech Research, 2013, 5(5), pp. 2588-2592 Sayyed, A.T.; Elham, R.Z.; Hamed, R.; Bagher, A.; Bijan, S.; Majid, S.; Abbas, S.; Mehrdad, F. Evaluation of anxiolytic, sedative-hypnotic and amnesic effects of novel 2-phenoxy phenyl-1,3,4-oxadizole derivatives using experimental models. Iran Journal of Pharmaceutical Research, 2015, 14, pp. 51–57 10.1155/2014/694060 10.1002/9783527645640 10.1016/j.apsusc.2014.12.019 10.1002/(SICI)1097-4628(20000222)75:8<1005::AID-APP5>3.0.CO;2-W 10.1055/s-0028-1129654 10.1016/j.reactfunctpolym.2014.02.004 10.1016/j.reactfunctpolym.2015.02.005 Chamari, W.; Marianna, B.; Lívia, B.; Magdolna, E.S.; Ilona, P. Optimization of liposomal encapsulation for ceftazidime for developing a potential eye drop formulation. Journal of Basic and Clinical Pharmacy, 2013, 4(3), pp. 73–75 10.1016/j.copbio.2015.03.018 10.1016/j.bmc.2015.05.055 10.1016/j.reactfunctpolym.2014.10.002 10.1016/j.cclet.2011.01.030 10.1016/j.jsps.2013.04.004 Guo-Qiang, H.; Li-Li, H.; Guo-Qiang, W.; Nan-Nan, D.; Xiao-Yi, W.; Tie-Yao, C.; Jun, Y.; Wei, W.; SongQiang, X.; Wen-Long, H. Part IV: design, synthesis and antitumor activity of fluoroquinolone C-3 heterocycles: bis-oxadiazole methylsulfide derivatives derived from ciprofloxacin. Acta Pharmaceutica Sinica, 2012, 47(8), pp. 1017−1022 Furniss, B.S.; Hannford, A.J.; Smith, P.W.G.; Tatchell, A.R. Vogel’s Text Book of Practical Organic Chemistry. John Wiley & Sons: New York, 5th edition, 1989, pp. 1076 10.1016/j.reactfunctpolym.2007.01.008 Reference method for brothdilution antifungal susceptibility testing of yeasts, Approved Standard, 2nd Edition, Clinical and Laboratory Standards Institute (USA), NCCLS document M27-A2, 2002, 22(15), 51p Hamini, K.N.; Hamdane, F.; Boutoutaou, R.; Kihal, M.; Henni, J.E. Antifungal activity of clove (Syzygium aromaticum L.) Essential oil against phytopathogenic fungi of tomato (Solanum lycopersicum L.) in Algeria. Journal of Experimental Biology and Agricultural Sciences, 2014, 2(5), pp. 448-454