Abstract (PDF) Graphical Abstract: The review is dedicated to the synthesis of 1,3-diaryl-2-propen-2-ones derived from aromatic methyl ketones. The article highlights advancements in the synthesis of chalcones and hybrid compounds based on chalcones containing 1,2,4-triazole, tetrazole-pyrazoline, and chromenol moieties. The biological activity of the synthesized compounds is comprehensively discussed.