Chemistry Journal of Moldova
- SCOPUS Journal Metrics for year 2023:
- CiteScore 0.9;
- Source Normalized Impact per Paper (SNIP) 0.094;
- SCImago Journal Rank (SJR) 0.133.
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NANOPARTICLES
Mihail Iacob
(downloads: 1147)
2. SYNTHESIS OF DIFFERENT STRUCTURAL TYPES
OF ZEOLITES IN THE
HALLOYSITE-DOLOMITE-OBSIDIAN SYSTEM
Gunel Mamedova
(downloads: 782)
3. A NOVEL GREEN SYNTHESIS OF NICKEL OXIDE
NANOPARTICLES USING ARABIC GUM
Saeid Taghavi Fardood, Ali Ramazani, Sajjad Moradi
(downloads: 657)
4. SYNTHESIS, CHARACTERIZATION AND
MOLECULAR DOCKING OF CHLORO-SUBSTITUTED
HYDROXYXANTHONE DERIVATIVES
Emmy Yuanita, Harno Dwi Pranowo, Mustofa Mustofa, Respati Tri Swasono, Jufrizal Syahri, Jumina Jumina
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5. ROLE OF CYCLODEXTRINS IN NEW
ANTIMYCOBACTERIAL FORMULATIONS
Veaceslav Boldescu, Fliur Macaev, Gheorghe Duca
(downloads: 469)
6. SYNTHETIC TRANSFORMATIONS OF
ENT-KAURENOIC ACID
Olga Morarescu
(downloads: 426)
7. INVESTIGATION OF VARIOUS INFLUENCING
FACTORS OF HYDROTHERMAL SYNTHESIS OF
ANALCIME ZEOLITE
Gunel Mamedova, Gunel Nasirli
(downloads: 422)
8. STUDIES ON THE WATER SOLUBILIZATION
PROCESSES OF OENOTANNINS AND THEIR
PHYSICO-CHEMICAL PROPERTIES
Gh. Duca, T. Lupaşcu, P. Vlad, V. Kulciţki, R. Nastas
(downloads: 411)
9. ORGANOCHLORINE PESTICIDES RESIDUES IN
SOIL OF SOROCA DISTRICT, REPUBLIC OF
MOLDOVA
Elena Culighin
(downloads: 381)
10. DESIGN AND SYNTHESIS OF TWO
BICYCLO[3.3.1]NONANE-STEROID
DERIVATIVES
Lauro Figueroa, Alejandra Garcimarero, Rolando Garcia, Francisco Diaz, Marcela Rosas, Virginia Mateu, Maria Lopez, Lenin Hau, Tomas Lopez, Abelardo Camacho, Yaritza Borges
(downloads: 362)
SYNTHESIS, CHARACTERIZATION AND MOLECULAR DOCKING OF CHLORO-SUBSTITUTED HYDROXYXANTHONE DERIVATIVES
Author(s):
Field: Organic chemistry
Type: Research paper
Issue: 2019 Volume 14, no.1
Pages: 68-76
Emmy Yuanita, Harno Dwi Pranowo, Mustofa Mustofa, Respati Tri Swasono, Jufrizal Syahri, Jumina Jumina
Field: Organic chemistry
Type: Research paper
Issue: 2019 Volume 14, no.1
Pages: 68-76
chlorination, chloro-substituted hydroxyxanthone, derivative, anticancer, molecular docking.
Full Text (PDF): Download
Abstract (PDF)
Graphical Abstract: In this study, the chloro-substituted hydroxyxanthones were prepared by cyclodehydration of acid derivatives and substituted phenol in the presence of Eaton reagent, followed by halogenations step to electrophilic substitution of chlorine in a moderate yield. The in vitro anticancer activity study on various cell lines revealed that the chloro functional group increases the anticancer activity of the hydroxyxanthone derivatives. The molecular docking study showed that there was a binding interaction between chloro-hydroxyxanthone and the amino acid residues such as Asp810, Cys809, Ile789, His790, and Leu644 of protein tyrosine kinase receptor.
Graphical Abstract: In this study, the chloro-substituted hydroxyxanthones were prepared by cyclodehydration of acid derivatives and substituted phenol in the presence of Eaton reagent, followed by halogenations step to electrophilic substitution of chlorine in a moderate yield. The in vitro anticancer activity study on various cell lines revealed that the chloro functional group increases the anticancer activity of the hydroxyxanthone derivatives. The molecular docking study showed that there was a binding interaction between chloro-hydroxyxanthone and the amino acid residues such as Asp810, Cys809, Ile789, His790, and Leu644 of protein tyrosine kinase receptor.
Downloads: 513