Chemistry Journal of Moldova

COMPARATIVE ANALYSIS AND APPLICATION OF NOVEL SPECTROPHOTOMETRIC APPROACHES AND BIOASSAY FOR FAST MACROLIDE QUANTIFICATIONIN TABLETS

Author(s):

Abdelghani Mahmoudi and Silvia De Francia


Field: Analytical chemistry
Type: Research paper
Pages: 9
Keywords:

spectrophotometric method, 1,2-naphthoquinone-4-sulphonate, phylloquinone, clarithromycin, bioassay.


Full Text (PDF): Download
 
https://doi.org/10.19261/cjm.2025.1312
 
Abstract (PDF)
Graphycal Abstract: Novel spectrophotometric method and bioassay using the Bacillus subtilis strain were developed for clarithromycin analysis. Experimental conditions were optimised and validated according to ICH guidelines. A comparative study was established, and the methods were successfully applied for the quantification of clarithromycin in solid dosage forms and can be used for pharmaceutical purposes.


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