Graphical Abstract: Proteins are the main components of living systems therefore they are a subject of study from different points of view. Under certain conditions, proteins are capable of self-organization forming oligomeric structures of various composition and new properties. The investigations of these transformations were carried out on two well known proteins: albumin and lyzozyme. It is shown that associates of albumin and lysozyme are formining in the stoichiometric ratios of 1:1, 1:2, 1:3, 1:4. A similar pattern is observed in the case of albumin dimer.