Chemistry Journal of Moldova

NOVEL INDIRECT SPECTROPHOTOMETRIC APPROACHES FOR SPIRAMYCIN QUANTIFICATION IN DOSAGE FORMS USING NAPHTHOQUINONE DERIVATIVE REAGENTS

Author(s):

Abdelghani Mahmoudi, Silvia De Francia, Yamina Boudinara, Hela Mahmoudi, Peixi Zhu


Field: Analytical chemistry
Type: Research paper
Issue: 2026 Volume 21, no.1
Pages: 34-43
Keywords:

spectrophotometry, spiramycin, 1,2-naphthoquinone-4-sulphonate, phylloquinone, charge-transfer complex, validation.


Full Text (PDF): Download
 
https://doi.org/10.19261/cjm.2026.1473
 
Graphycal Abstract: New spectrophotometric techniques using charge-transfer reactions between naphthoquinone reagents and spiramycin were developed and validated according to ICH guidelines. These procedures were successfully applied to the analysis of spiramycin in pharmaceutical formulations. The suggested approaches are simple, effective, and trustworthy enough, and highlighting their utility in routine quality control. 



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