Chemistry Journal of Moldova

Accepted papers

Oksana Stavinskaya, Iryna Laguta, Pavlo Kuzema, Iryna Skorochod, Alla Roy, Ivan Kurdish

Field: Ecological chemistry
Type: Research paper
caffeic acid, fumed silica, composite, antioxidant, radical scavenger, antimicrobial activity.
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Graphical Abstract: The work was aimed at preparing the CA+A300 composite consisting of caffeic acid (CA) and fumed silica (A300) and at comparing the properties of CA in the solution and in the composite. The results showed that the solution and the composite are effective antioxidant/antimicrobial agents and that inclusion of CA in the CA+A300 composite provides its gradual release into solutions and reaction mixtures, thus ensuring a prolonged action of the compound.


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Marina Zveaghintseva, Eugenia Stingaci, Serghei Pogrebnoi, Lucian Lupascu, Alic Barba, Gheorghe Duca, Vladimir Valica, Livia Uncu, Victor Kravtsov, Dumitru Terteac, Alexandr Brinzan, Fliur Macaev

Field: Supramolecular chemistry
Type: Research paper
β-cyclodextrin, dehydroabietic acid, 2-tert-butyl-3-(1H-1,2,4-triazol-1-yl)-2H-chromen-2-ol, chromenol-triazol hybrid, antimicrobial activity.
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Graphical Abstract. In this work new methods to obtain complexes from β-cyclodextrin and dehydroabietic acid with chromenol-triazol hybrid with the sizes limits of approximately 0.1-250 μm are reported. Kneading, co-evaporation and co-precipitation for the resolution of racemic 2-tert-butyl-3-(1H-1,2,4-triazol-1-yl)-2H-chromen-2-ol for obtaining micro- and nanoparticles have been optimized. In vitro dissolution studies of the synthesized compounds in phosphate buffer (pH 6.8) showed an improved dissolution rate of chromenol-triazol hybrid in the inclusion complexes compared to the free form. The obtained β-complexes of β-cyclodextrin loaded with dehydroabietitoic acid and chromenol hybrid showed good antibacterial activity with MIC and MBC values ranging from 0.72 to 44.45 μM.


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