Supplementary Material (PDF)
Graphical Abstract: An eco-friendly and environmentally benign synthesis of 3,4,5-substituted furan-2(5H)-ones employing Iranian seedless barberry or zereshk (Berberis integerrima ‘Bidaneh’, Berberidaceae) as a biocatalyst was developed. The merits of this method include the environmentally friendly reaction conditions, simple operation, broad substrate, satisfied yields and generate less waste than the conventional chemical reagents.