Chemistry Journal of Moldova

FROM (-)-SCLAREOL TO NORLABDANE HETEROCYCLIC HYBRID COMPOUNDS

Author(s):

Alexandru Ciocarlan


Field: Natural product chemistry and synthesis
Type: Review
Pages: 16
Keywords:

(-)-sclareol, norlabdane-heterocyclic compound, antimicrobial activity, biological activity.


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Graphical Abstract: This review relates to chemistry of the well-known biologically active natural labdane diterpenoid (-)-sclareol easily available from Clary sage (Salvia sclarea L.). It is mainly used in industry, especially for synthesis of fragrance compounds and natural analogs. The paper covers achievements on the synthesis, structure determination and biological activity of molecular hybrid compounds bearing hydrazide and thiosemicarbazone fragments or diazine, 1,2,4-triazole, carbazole, 1,3-thiazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole units prepared based on it. 


 



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