Graphical Abstract: The paper aims to analyze the current state of affairs with water resources in Moldova, the challenges it faces for its national human and economic development, having in mind that the water resources are quite limited in Moldova, which encounters pollution, degradation influenced by climate change and unwise human activity to their biodiversity and ecosystems, availability and accessibility. It also attempts to highlight the relationship between climate change and water resources in Moldova, which has adverse effects on both environment and people’s health, and raise significant hurdles to the international, regional and sectoral development.