Chemistry Journal of Moldova

INHIBITION OF IN VITRO NITROSATION OF NORNICOTINE

Author(s):

Diana Porubin


Field: Ecological chemistry
Type: Research paper
Issue: 2007 Volume 2, no.1
Pages: 78-82
Keywords:

N-nitrosonornicotine, nitrosation, inhibition, grape seed extract, polyphenol.


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DOI:
dx.doi.org/10.19261/cjm.2007.02(1).11

Graphical Abstract:
 The inhibition of nornicotine nitrosation was studied. The concentration of nornicotine was 100 μM and nitrite 1000 μM. As inhibitors were used following compounds: ascorbic acid (as reference) (800, 1000, and 5000 μM), dihydroxyfumaric acid (1000 μM), (+)catechin (1000 μM), resveratrol (1000 μM), tartaric acid (1000 μM), quercetin (1000 μM), and grape seed extract (50, 100, 150 μg/ml). The best inhibitory effect was obtained for AAs at 5000 μM (90.7%), (+)Ct (95.5 %) and GSE at 150 μg/ml (96.1%). The small inhibitory effect was observed for TA – 22,5%.


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