Chemistry Journal of Moldova

MILD ACIDIC CHARCOAL CATALYZED SYNTHESIS OF 3,4-DIHYDROPYRIMIDIN-2(1H)-ONE/-THIONE DERIVATIVES

Author(s):

Rajendra Patil, Jagdish Chavan, Shivnath Patel, Vaishali Shinde, Anil Beldar


Field: Organic chemistry
Type: Research paper
Pages: 8
Keywords:

Biginelli reaction, acetic acid, acidic charcoal, microwave irradiation.


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Graphical Abstract: A green and efficient method for the multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones using acetic acid supported on activated charcoal as a mild acid catalyst in ethanol under both conventional as well as microwave irradiation conditions has been developed. The catalyst system found more efficient under microwave irradiation conditions than conventional conditions with shorter reaction times and excellent yields.


 


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