Chemistry Journal of Moldova

RESIN ACIDS AS RAW MATERIAL FOR THE PREPARATION OF CYCLODEXTRIN COMPLEXES LOADED WITH DEHYDROABIETITOIC ACID AND CHROMENOL HYBRID

Author(s):

Marina Zveaghintseva, Eugenia Stingaci, Serghei Pogrebnoi, Lucian Lupascu, Alic Barba, Gheorghe Duca, Vladimir Valica, Livia Uncu, Victor Kravtsov, Dumitru Terteac, Alexandr Brinzan, Fliur Macaev


Field: Supramolecular chemistry
Type: Research paper
Pages: 11
Keywords:

β-cyclodextrin, dehydroabietic acid, 2-tert-butyl-3-(1H-1,2,4-triazol-1-yl)-2H-chromen-2-ol, chromenol-triazol hybrid, antimicrobial activity.


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Graphical Abstract. In this work new methods to obtain complexes from β-cyclodextrin and dehydroabietic acid with chromenol-triazol hybrid with the sizes limits of approximately 0.1-250 μm are reported. Kneading, co-evaporation and co-precipitation for the resolution of racemic 2-tert-butyl-3-(1H-1,2,4-triazol-1-yl)-2H-chromen-2-ol for obtaining micro- and nanoparticles have been optimized. In vitro dissolution studies of the synthesized compounds in phosphate buffer (pH 6.8) showed an improved dissolution rate of chromenol-triazol hybrid in the inclusion complexes compared to the free form. The obtained β-complexes of β-cyclodextrin loaded with dehydroabietitoic acid and chromenol hybrid showed good antibacterial activity with MIC and MBC values ranging from 0.72 to 44.45 μM.


 


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