Chemistry Journal of Moldova

SPECTROPHOTOMETRIC STUDIES OF SANGUINARINE-Β-CYCLODEXTRIN COMPLEX FORMATION

Author(s):

Veaceslav Boldescu,Irina Kacso, Ioan Bratub and Gheorghe Duca


Field: Industrial chemistry
Type: Research paper
Issue: 2008 Volume 3, no.1
Pages: 85-88
Keywords:

sanguinarine, β-cyclodextrin, inclusion complex, UV-vis spectrophotometry, association constant.


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Abstract (JPEG)

DOI:
dx.doi.org/10.19261/cjm.2008.03(1).18

Graphical Abstract:
The main aim of this study was to investigate the influence of pH and the presence of hydrophilic polymer polyvinylpyrrolidone on the formation of sanguinarine-β-cyclodextrin (SANG
-β-CD) inclusion complex. Spectrophotometric studies of the SANG-β-CD systems in the presence and without 0.1 % PVP at the pH 5.0 did not show any evidence of the complex formation. However, the same systems showed several obvious evidences at the pH 8.0: the hyperchromic and the hypochromic effects and the presence of the isosbestic point in the region of 200 –210 nm. The association constants calculated by three linear methods: Benesi-Hildebrand, Scott and Scatchard, were two times higher for the systems with addition of 0.1% PVP than for the systems without it.


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