Abstract (PDF)
Graphical Abstract: The study describes the synthesis of novel tetranorlabdane compounds bearing 1,3,4-thiadiazole units and intermediary tetranorlabdane compounds with thiosemicarbazone fragment. The structures of the synthesized compounds were confirmed using IR and 1H, 13C, and 15N NMR spectroscopy. The in vitro antifungal and antibacterial activities of the tetranorlabdane compounds with thiosemicarbazone and 1,3,4-thiadiazole units have been evaluated. One of the tested compounds has an excellent activity against five strains of fungi and two species of bacteria at minimum inhibitory concentration values of 0.125 and 2.5 µg/mL, respectively.