Chemistry Journal of Moldova

SYNTHESIS OF QUERCETIN FUNCTIONALIZED CHITOSAN AND DETERMINATION OF ANTIOXIDANT PROPERTIES

Author(s):

Maria Gonta, Gheorghe Duca, Elena Sirbu, Stefan Robu, Larisa Mocanu


Field: Supramolecular chemistry
Type: Research paper
Pages:
Keywords:

chitosan, functionalization, grafting, quercetin, antioxidant activity.


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https://doi.org/10.19261/cjm.2023.910

Graphical Abstract: This paper presents the synthesis of a copolymer with reducing properties obtained by functionalizing chitosan with quercetin and determining the antioxidant activity of the derivatives obtained depending on the molar mass of the polymer. For this purpose, low molecular weight chitosan was obtained by oxidizing industrial chitosan with hydrogen peroxide and functionalizing with quercetin by the covalent grafting method. The comparative antioxidant properties of the composite obtained by grafting technical chitosan with quercetin and by grafting low molecular weight chitosan were studied by the DPPH (2,2-diphenyl-1-picrylhydrazyl radical) method. The obtained results indicate that a decrease in the molecular weight of chitosan contributed to its grafting with quercetin. As a result, the functionalized polymer composite acquired a higher antioxidant activity and can be successfully used to inhibit the oxidation of various organic substrates in the cosmetic, food and pharmaceutical industries. 





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