Chemistry Journal of Moldova

2022 Volume 17, no.2


Marina Zveaghintseva, Eugenia Stingaci, Serghei Pogrebnoi, Lucian Lupascu, Alic Barba, Gheorghe Duca, Vladimir Valica, Livia Uncu, Victor Kravtsov, Dumitru Terteac, Alexandr Brinzan, Fliur Macaev

Field: Supramolecular chemistry
Type: Research paper
Issue: 2022 Volume 17, no.2
Pages: 109-119
Keywords: β-cyclodextrin, dehydroabietic acid, 2-tert-butyl-3-(1H-1,2,4-triazol-1-yl)-2H-chromen-2-ol, chromenol-triazol hybrid, antimicrobial activity.
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Graphical Abstract. In this work new methods to obtain complexes from β-cyclodextrin and dehydroabietic acid with chromenol-triazol hybrid with the sizes limits of approximately 0.1-250 μm are reported. Kneading, co-evaporation and co-precipitation for the resolution of racemic 2-tert-butyl-3-(1H-1,2,4-triazol-1-yl)-2H-chromen-2-ol for obtaining micro- and nanoparticles have been optimized. In vitro dissolution studies of the synthesized compounds in phosphate buffer (pH 6.8) showed an improved dissolution rate of chromenol-triazol hybrid in the inclusion complexes compared to the free form. The obtained β-complexes of β-cyclodextrin loaded with dehydroabietitoic acid and chromenol hybrid showed good antibacterial activity with MIC and MBC values ranging from 0.72 to 44.45 μM.


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