Organic chemistry

SYNTHESIS AND ANTIMICROBIAL EVALUATION OF SYMMETRICAL DIQUATERNARY AMMONIUM SALTS BEARING BIS-1,3,4-OXADIAZOLE RINGS MOIETIES

Author(s):

Sofiane Daoudi, Tahar Benaissa, Djallal Eddine Adli, Nisserine Hamini-Kadar

Field: Organic chemistry
Type: Research paper
Issue: 2016 Volume 11, no.1
Pages: 55-60

Keywords: 1,3,4-oxadiazole, quaternary ammonium compounds, DMAEMA, DEAEMA, antimicrobial activities.
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Abstract (PDF)

DOI: dx.doi.org/10.19261/cjm.2016.11(1).07

Graphical Abstract: This study describes the synthesis of some novel compounds containing bis-1,3,4-oxadiazole bearing quaternary ammonium salt moieties. The newly synthesized compounds were evaluated for their antibacterial activity against various gram-positive and gram-negative strains of bacteria, and the antifungal activities were tested against three phytopathogenic fungi namely, Fusarium oxysporum, Fusarium commune and Fusarium rodelens.

The article is Open Access by CC-BY 4.0 License

Cite this article as:

S. Daoudi, T. Benaissa, D.E. Adli, N. Hamini-Kadar. Synthesis and Antimicrobial Evaluation of Symmetrical Diquaternary Ammonium Salts Bearing Bis-1,3,4-Oxadiazole Rings Moieties. Chemistry Journal of Moldova, 2016, 11(1), pp. 55-60. DOI: dx.doi.org/10.19261/cjm.2016.11(1).07

Article Source: Synthesis and Antimicrobial Evaluation of Symmetrical Diquaternary Ammonium Salts Bearing Bis-1,3,4-Oxadiazole Rings Moieties.

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Downloads: 102

NEW N-GLUCOSYLATED SUBSTITUTED ANILINES

Author(s):

Vsevolod Pogrebnoi

Field: Organic chemistry
Type: Research paper
Issue: 2015 Volume 10, no.2
Pages: 62-67

Keywords: N-glucosylated anilines, (+)-D-glucose, 4-chloroaniline, 3,5-dibromoaniline, Convolutamydines A-E.
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Abstract (PDF)

DOI: dx.doi.org/10.19261/cjm.2015.10(2).08

Graphical Abstract: The reaction of (+)-D-glucose with 4-chloroaniline or 3,5-dibromoaniline leads almost exclusively to the β-configuration of glucosylated anilines. The acetylating of 2-(3,5-dibromophenylamino)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is less selective than in case of the 2-(4-chlorophenylamino)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol.

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A SEQUENTIAL DUAL CLEAVAGE OF THE ARYLSULFAMATE LINKER TO PROVIDE BOTH SULFAMATE AND PHENOL DERIVATIVES

Author(s):

Diane Fournier, Liviu Ciobanu, Donald Poirier

Field: Organic chemistry
Type: Research paper
Issue: 2015 Volume 10, no.2
Pages: 68-76

Keywords: solid-phase synthesis, linker, sulfamate, phenol, library.
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Abstract (PDF)

DOI: dx.doi.org/10.19261/cjm.2015.10(2).09

Graphical Abstract: Tyramine sulfamate was linked to the trityl chloride resin and this polymeric support used to introduce two levels of molecular diversity by formation of peptide bonds. A dual cleavage strategy next generated in a sequential way (without resin split) two types of compounds (phenol and arylsulfamate derivatives), which are therapeutically attractive types of compounds.

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THE SYNTHESIS OF NEW SPIROLACTONES FROM SUBSTITUTED ISATINS

Author(s):

Natalia Sucman, Vsevolod Pogrebnoi, Mykola Obushak, Elena Melnic, Victor Kravtsov, Fliur Macaev

Field: Organic chemistry
Type: Research paper
Issue: 2015 Volume 10, no.1
Pages: 64-70

Keywords: spirolactones, isatins, triphenylphosphine, dimethyl acetylenedicarboxylate.
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Abstract (PDF)

DOI: dx.doi.org/10.19261/cjm.2015.10(1).09

Graphical Abstract: Described synthesis of 5-bromo substituted oxindoles linkages in spirocyclic butenolides exhibit relatively dependence of the structure-reactivity relationships of N-substituted isatines, dimethyl acetylenedicarboxylate and triphenylphoshine. The study of the stereochemistry of the atom C(2) of the spiro compounds was also unambiguously confirmed by single crystal X-ray analysis.

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SUBSTITUTED 1,3-PHENYL(PYRIDYL) PROPENONES AND DERIVATIVES WITH THIOSEMICARBAZIDIC GROUPS. STRUCTRURE – (HL-60) ANTILEUKEMIA ACTIVITY RELATIONSHIP

Author(s):

Ana Popusoi, Nicanor Barba, Aurelian Gulea, Jenny Roy, Donald Poirier

Field: Organic chemistry
Type: Research paper
Issue: 2014 Volume 9, no.2
Pages: 67-73

Keywords: chalcones, isothiocyanatopropenones, thioureas, antileukemia activity
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Abstract (PDF)

DOI: dx.doi.org/10.19261/cjm.2014.09(2).10

Graphical Abstract: 3-(4-(Dimethylamino)phenyl-1-(4-isothiocyanatophenyl)prop-2-en-1-one was obtained from the corresponding N,N-dimethylthyoureas by elimination of dimethylamine at heating with gaseous hydrogen chloride in chloroform and 1-(4-isothiocyanatophenyl)-3-(pyridin-2-il)prop-2-en-1-one by treating 1,1-dimethyl-3-(4-(3-(pyridin-2-il)-acryloyl)-phenyl)thyourea with acetic anhydride. For all obtained compounds in the course of reaction the antileukemia activity was investigated.

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ROLE OF CYCLODEXTRINS IN NEW ANTIMYCOBACTERIAL FORMULATIONS

Author(s):

Veaceslav Boldescu, Fliur Macaev, Gheorghe Duca

Field: Organic chemistry
Type: Review
Issue: 2014 Volume 9, no.1
Pages: 8-13

Keywords: cyclodextrin, nano-encapsulation, tuberculosis, mycobecteria, cholesterol
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Abstract (PDF)

DOI: dx.doi.org/10.19261/cjm.2014.09(1).01

Graphical Abstract: This paper is dedicated to the role of cyclodextrins in new formulations for the treatment of infections with Mycobacterium tuberculosis that are in the process of design and development. Cyclodextrins play the role of solubilizing agents and promoters of the antimycobacterial substances penetration inside the mycobacterial cell.

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ANTIMICROBIAL REAGENTS AS FUNCTIONAL FINISHING FOR TEXTILES INTENDED FOR BIOMEDICAL APPLICATIONS. I. SYNTHETIC ORGANIC COMPOUNDS

Author(s):

Madalina Zanoaga, Fulga Tanasa

Field: Organic chemistry
Type: Review
Issue: 2014 Volume 9, no.1
Pages: 14-32

Keywords: antimicrobial agents, structure, fibers, medical textiles
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Abstract (PDF)

DOI: dx.doi.org/10.19261/cjm.2014.09(1).02

Graphical Abstract: This article offers an overview of some contemporary antimicrobial (biocides and biostatics) agents used as functional finishing for textiles intended for biomedical applications. It reviews only synthetic agents, namely quaternary ammonium compounds, halogenated phenols, polybiguanides, N-halamines, and renewable peroxides, as a part of an extensive study currently in progress.

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STUDY OF PROPERTIES OF SOME POLYETHYLENE-CLAY NANOCOMPOSITES: INFLUENCE OF PREPARATION METHOD ON THE DEGREE OF CLAY INTERCALATION/EXFOLIATION

Author(s):

Fulga Tanasa, Madalina Zanoaga

Field: Organic chemistry
Type: Research paper
Issue: 2014 Volume 9, no.1
Pages: 106-111

Keywords: polymer-clay nanocomposites, preparation, properties, exfoliation, intercalation
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Abstract (PDF)

DOI: dx.doi.org/10.19261/cjm.2014.09(1).13

Graphical Abstract: Nanocomposites based on HDPE and HDPE-g-MA, as matrix, and nanoclay Cloisite 20A, as filler, were obtained by melt compounding and solution blending, and their properties were comparatively studied in order to establish the dependence of the clay degree of exfoliation/intercalation on the preparation procedure.

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MOLECULAR CONCEPTS OF MACROPHAGE TARGETING

Author(s):

Veaceslav Boldescu, Valeriu Crudu, Natalia Sucman, Serghei Pogrebnoi, Marina Zviaghinţeva, Eugenia Stîngaci, Vsevolod Pogrebnoi, Fliur Macaev

Field: Organic chemistry
Type: Review
Issue: 2013 Volume 8, no.2
Pages: 21-31

Keywords: macrophage receptor targeting, macrophage enzyme targeting, inﬂammatory disorders, tuberculosis, cancer
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Abstract (PDF)

DOI: dx.doi.org/10.19261/cjm.2013.08(2).02

Graphical Abstract: Macrophages play an important role in the pathological development of different diseases. Therefore, macrophage targeting represents an important challenge in design of new medicines. This review gives a general presentation of small molecule-recognition concepts used for macrophage targeting. It describes mechanisms and systems for macrophage-targeted delivery, their obtaining and application.