Chemistry Journal of Moldova

Organic chemistry

Author(s):

Maryam Shokoohian, Nourallah Hazeri, MalekTaher Maghsoodlou, Mojtaba Lashkari


Field: Organic chemistry
Type: Research paper
Issue: 2019 Volume 14, no.2
Pages: 97-104
Keywords: one-pot reaction, multi-component reaction, pyridine-2(1H)-one derivative, ultrasonication, 4-(dimethylamino)pyridine.
Full Text (PDF): Download
Graphical Abstract: 4-(Dimethylamino)pyridine was found to be an efficient homogenous catalyst for one-pot multi-component reactions between hydrazine monohydrate, ethyl cyanoacetate, ketone, and malononitrile for the synthesis of 1,6-diamino-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitrile derivatives using ultrasonication at room temperature in ethanol solution within 35-50 min with yields of over 90%.
 



Downloads: 121

Author(s):

Serghei Curlat


Field: Organic chemistry
Type: Review
Issue: 2019 Volume 14, no.2
Pages: 32-55
Keywords: (+)-3-carene, epoxidation, sulphide, aminoalcohol, azidoalcohol, aziridine.
Full Text (PDF): Download

 
Abstract (PDF)
Graphical Abstract: This review presents last decade and some past especially relevant studies in the field of (+)-3-carene synthetic transformations. This paper discusses exclusively the transformations of (+)-3-carene, proceeding with the retention of the native bicyclic carbon skeleton. The data concerning the features of epoxidation and oxidation reactions of (+)-3-carene, the synthesis of sulphur- and selenium-containing derivatives and their use in asymmetric synthesis are given. It also describes methods for producing amino derivatives of (+)-3-carene, substituted heterocycles based on it, reactions for the preparation of aziridines, azido-alcohols and azidoamines, as well as chiral phosphites as bidentate ligands.


 


Downloads: 143

Author(s):

Emmy Yuanita, Harno Dwi Pranowo, Mustofa Mustofa, Respati Tri Swasono, Jufrizal Syahri, Jumina Jumina


Field: Organic chemistry
Type: Research paper
Issue: 2019 Volume 14, no.1
Pages: 68-76
Keywords: chlorination, chloro-substituted hydroxyxanthone, derivative, anticancer, molecular docking.
Full Text (PDF): Download

 
Abstract (PDF)
Graphical Abstract: In this study, the chloro-substituted hydroxyxanthones were prepared by cyclodehydration of acid derivatives and substituted phenol in the presence of Eaton reagent, followed by halogenations step to electrophilic substitution of chlorine in a moderate yield. The in vitro anticancer activity study on various cell lines revealed that the chloro functional group increases the anticancer activity of the hydroxyxanthone derivatives. The molecular docking study showed that there was a binding interaction between chloro-hydroxyxanthone and the amino acid residues such as Asp810, Cys809, Ile789, His790, and Leu644 of protein tyrosine kinase receptor.


 


Downloads: 454

Author(s):

Farzaneh Mohamadpour, Malek Taher Maghsoodlou, Mojtaba Lashkari, Reza Heydari, Nourallah Hazeri


Field: Organic chemistry
Type: Research paper
Issue: 2018 Volume 13, no.1
Pages: 74-86
Keywords: tartaric acid, polysubstituted quinolines, 12-aryl-tetrahydrobenzo[α]xanthene-11-ones, 1,8-dioxo-octahydroxanthenes, 14-aryl-14H-dibenzo[α,j]xanthenes.
Full Text (PDF): Download

Graphical Abstract: This method reported the use of tartaric acid as a green and highly efficient catalyst for the convenient synthesis of polysubstituted quinolines and xanthenes derivatives in excellent yields under solvent-free conditions. The main advantages of this one-pot procedure are the green and economic availability of the catalyst, simple experimental and work-up procedures.


 


Downloads: 198

Author(s):

Gheorghe Duca, Aculina Aricu, Lidia Lungu, Nadejda Tenu, Alexandru Ciocarlan, Yacob Gutu, Ion Dragalin, Alic Barba


Field: Organic chemistry
Type: Research paper
Issue: 2018 Volume 13, no.1
Pages: 69-73
Keywords: sesquiterpenoids, N-substituted amides, heterocyclic amines, diazine, 1,2,4-triazole, carbazole, synthesis.
Full Text (PDF): Download
Graphical Abstract: The study describes the synthesis of 11-homodrim-6,8-dien-12-oic acid N-substituted amides containing diazine, 1,2,4-triazole and carbazole rings based on commercially available sclareolide. The mentioned compounds were prepared for the first time by interaction of the generated in situ acyl chloride with some heterocyclic amines: 2- and 4-aminopyrimidine, 2-aminopyrazine, 3-amino-1,2,4-triazole and N-aminocarbazole. Their structures were fully elucidated by elemental and spectral analyses (IR, 1H and 13C NMR).


 


Downloads: 172

Author(s):

Bin Yuan, Wei Hu, Song Lv, Jieyang Huang, Kecheng Huang


Field: Organic chemistry
Type: Research paper
Issue: 2017 Volume 12, no.1
Pages: 81-86
Keywords: diphosphonium salts, ω,ω´-dibromo alkane, synthesis, bactericidal activity.
Full Text (PDF): Download

Graphical Abstract: Eight new aliphatic symmetrical diphosphonium salts were synthesized by reacting ω,ω´-dibromoalkanes with triphenylphosphine or tributylphosphine using N,N-dimethyl acetamide as a solvent at 140~150°C for 16~20 h under a nitrogen atmosphere.

 


Downloads: 112

Author(s):

Demet Gürbüz, Aydin Tavman, Adem Cinarli, Ismail Boz


Field: Organic chemistry
Type: Research paper
Issue: 2016 Volume 11, no.2
Pages: 58-67
Keywords: dimethoxyphenylbenzimidazoles, spectral characterization, density functional theory, charge distribution, geometry optimization.
Full Text (PDF): Download
 
Graphical Abstract: 5,6-Dichloro/dimethyl-2-(2´,3´/2´,4´/2´,5´/3´,4´/3´,5´-dimethoxyphenyl)-1H-benzimidazoles were synthesized and characterized experimentally and theoretically. The optimized molecular geometry, zero point energy, dipole moment, ESE and charge distributions were calculated by Gaussian 09 using DFT method. The calculated energy values with ZPE correction and DFT show that the methyl derivatives are more stable than the chloro forms.


Downloads: 77

Author(s):

Nourallah Hazeri, Razieh Doostmohammadi, Belgheis Adrom, Mojtaba Lashkari, Malek Taher Maghsoodlou


Field: Organic chemistry
Type: Research paper
Issue: 2016 Volume 11, no.2
Pages: 68-73
Keywords: three-component reaction, dialkyl acetylenedicarboxylates, furan-2(5H)-ones, aldehydes, barberry juice.
Full Text (PDF): Download
 
Supplementary Material (PDF)
Graphical Abstract:
 An eco-friendly and environmentally benign synthesis of 3,4,5-substituted furan-2(5H)-ones employing Iranian seedless barberry or zereshk (Berberis integerrima ‘Bidaneh’, Berberidaceae) as a biocatalyst was developed. The merits of this method include the environmentally friendly reaction conditions, simple operation, broad substrate, satisfied yields and generate less waste than the conventional chemical reagents.


Downloads: 91

Author(s):

Sofiane Daoudi, Tahar Benaissa, Djallal Eddine Adli, Nisserine Hamini-Kadar


Field: Organic chemistry
Type: Research paper
Issue: 2016 Volume 11, no.1
Pages: 55-60
Keywords: 1,3,4-oxadiazole, quaternary ammonium compounds, DMAEMA, DEAEMA, antimicrobial activities.
Full Text (PDF): Download

DOI:
dx.doi.org/10.19261/cjm.2016.11(1).07

Graphical Abstract:
 This study describes the synthesis of some novel compounds containing bis-1,3,4-oxadiazole bearing quaternary ammonium salt moieties. The newly synthesized compounds were evaluated for their antibacterial activity against various gram-positive and gram-negative strains of bacteria, and the antifungal activities were tested against three phytopathogenic fungi namely, Fusarium oxysporum, Fusarium commune and Fusarium rodelens.





The article is Open Access by CC-BY 4.0 License

Cite this article as:
S. Daoudi, T. Benaissa, D.E. Adli, N. Hamini-Kadar. Synthesis and Antimicrobial Evaluation of Symmetrical Diquaternary Ammonium Salts Bearing Bis-1,3,4-Oxadiazole Rings Moieties. Chemistry Journal of Moldova, 2016, 11(1), pp. 55-60. DOI: dx.doi.org/10.19261/cjm.2016.11(1).07

Article Source: Synthesis and Antimicrobial Evaluation of Symmetrical Diquaternary Ammonium Salts Bearing Bis-1,3,4-Oxadiazole Rings Moieties

Download article metadata:
CrossRef                       BibTeX                  CERIF
Google Scholar            DataCite               Dublin Core


Downloads: 100

Author(s):

Vsevolod Pogrebnoi


Field: Organic chemistry
Type: Research paper
Issue: 2015 Volume 10, no.2
Pages: 62-67
Keywords: N-glucosylated anilines, (+)-D-glucose, 4-chloroaniline, 3,5-dibromoaniline, Convolutamydines A-E.
Full Text (PDF): Download

DOI:
dx.doi.org/10.19261/cjm.2015.10(2).08

Graphical Abstract:
 The reaction of (+)-D-glucose with 4-chloroaniline or 3,5-dibromoaniline leads almost exclusively to the β-configuration of glucosylated anilines. The acetylating of 2-(3,5-dibromophenylamino)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol is less selective than in case of the 2-(4-chlorophenylamino)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol.



Downloads: 43