Chemistry Journal of Moldova

Graphycal Abstract: The chemical composition and antimicrobial activity of Narcissus poeticus L. essential oil and Rosa damascena Mill. absolutes of Moldovan origin were studied. Using GC–MS analysis 28 constituents of N. poeticus essential oil and 37 of R. damascena absolutes were identified. The γ-terpineol (52.62%) was the main component of N. poeticus oil, while the  phenylethyl alcohol predominated in R. damascena absolutes (59.85–78.17%). Both products exhibited strong in vitro antibacterial and antifungal activity against four bacterial strains and two fungal species, with effective concentrations of 150–300 μg/mL and 300–600 μg/mL, respectively.

Graphycal Abstract: Two methods for synthesizing MgO nanoparticles using sodium lauryl sulphate and Aloe Vera extract as dispersing agents are described. Varying dispersing agent quantities and calcination temperatures were applied. The morphology and size were characterized using SEM-EDX and XRD, confirming successful synthesis and structure of the MgO nanoparticles.

Graphycal Abstract: A new cadmium(II) polymeric complex was synthesized under solvothermal conditions by the reaction of 5-(4-carboxy-5-methyl-1H-1,2,3-triazol-1-yl)isophthalic acid (H₃L) with cadmium nitrate tetrahydrate in a mixture of N,N-dimethylacetamide and water. The polymeric complex is an infinite 2D coordination polymer with the general formula {[Cd₃L₂(H₂O)6]·2H₂O}_n. The two-dimensional coordination polymer {[Cd₃L₂(H₂O)₆]}n presents p–p stacking interactions between benzene rings of adjacent 2D coordination polymers, which contribute along with numerous O-H---O H-bonds to the assembly of a 3D supramolecular assembly. The intense photoluminescence emission of cadmium(II) complex is observed in the blue-violet region of the spectrum.

Graphycal Abstract: Hydro-methanolic extracts of Bunium ferulaceum leaves, flowering heads, and tubers show organ-dependent phytochemical variation. Leaves are richest in phenolics and flavonoids, while tubers contain the highest triterpene levels. Polyphenol content correlates strongly with antibacterial activity, whereas triterpenes are tightly linked to anti-inflammatory effects. These complementary chemical–biological relationships highlight the plant’s multifunctional pharmacological potential, supporting further isolation and mechanistic studies. 

 

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Graphycal Abstract: In this work, the synthesis of Schiff bases derived from trans-(R,R)-diaminocyclohexane by microwave irradiation (MW) is presented. The reaction yields varied between 31% and 69%, being influenced by the electronic nature of the substituents (H, Cl, Br, NO₂, MeO, t-BuO, BnO, and 4-(4-Me)PhO) and the reaction temperature. The spectrophotometric properties of the products were investigated by UV-Vis spectrophotometry, revealing bathochromic and hypso-chromic effects attributable to the different substituent groups. These effects were interpreted by DFT calculations with the B3LYP functional at the 6-311G(d,p) level. The results suggest that the electronic properties of the substituents in the para position have a significant impact on the spectroscopic characteristics of the Schiff bases.

 

Graphycal Abstract: Lipid fractions from Helianthus annuus L. pollen collected across three Moldovan agroclimatic zones were analyzed via GC-MS after Soxhlet extraction, saponification, and methylation. Chromatographic profiling resolved >40 constituents, including: Polyunsaturated fatty acid esters (e.g., methyl linolenate, a ω-3 precursor); Diterpenoid derivatives (methyl labdatrien-19-oate); Oxygenated sterols (lanostan-3-one); Lipophilic vitamins (α-tocopherol, retinol derivatives). Chemometric analysis revealed climate-induced shifts in metabolite profiles, with heat and drought favoring terpenoid accumulation. Results highlight sunflower pollen as a structurally rich source of bioactive lipids with nutraceutical potential.

 

Graphycal Abstract: The contribution of in silico analysis in the development of corrosion inhibitors field by predicting adequate new molecules that could be employed for this purpose. QSAR analysis of already published experimental results of corrosion inhibition efficiency (IE%) of mild steel in acidic media for eighteen furan derivatives was performed.

 

Graphycal Abstract: The synthesis of three structurally distinct copper(II) coordination compounds with iminodiacetic acid (H₂IDA) as ligand was achieved by varying the reaction pH. Under neutral conditions (pH 6–6.5), compound 1 formed as a two-dimensional ionic coordination polymer, {[NH₂(CH₃)₂]₂[Cu₃(IDA)₄]·1.75H₂O}ₙ, consisting of layered [Cu₃(IDA)₄]²ₙ⁻ anions stabilized by hydrogen-bonding networks. Under basic conditions (pH 8–8.5), compound 2 was obtained as a neutral 2D molecular polymer, {[Cu₃(IDA)₂(IDAH)₂]·5H₂O}ₙ, built from trinuclear copper units bridged by bi- and monodeprotonated ligands. Under acidic conditions (pH 3), compound 3, ((CH₃)₂OH)₂[Cu(IDA)₂]·[Cu(IDAH)₂], was isolated as an ionic structure containing neutral and anionic mononuclear complexes charge-balanced by protonated dimethylether cations.

 

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Graphycal Abstract: Melissa officinalis L. and Urtica dioica L. were evaluated for their phytochemical composition and antioxidant and anti-lithiatic activities. LC-MS/MS analysis showed that M. officinalis contained a more diverse profile, especially flavonoids and phenolic acids enriched in the ethyl acetate fraction, while U. dioica demonstrated a simpler composition dominated by myricetin, riboflavin, sinapic acid, catechin, and β-carotene in its aqueous fraction. M. officinalis ethyl acetate extract showed the strongest antioxidant capacity in DPPH, ABTS, and FRAP assays. Its aqueous extract also exhibited notable anti-lithiatic activity, inhibiting calcium oxalate crystal formation by 87.12% at 2 mg/mL.

 

 

Graphycal Abstract: Concentrations of fluoride ions in the Dniester river and Dubasari reservoir, located on the territory of the Republic of Moldova, were analysed for 2011–2024. They ranged 0.05–1.07 mg/L, with higher values during low-water periods. Despite seasonal sampling, no clear dynamics were observed, due to altered hydrological regime. Fluoride levels were lower than the World Health Organization for drinking water.