Chemistry Journal of Moldova

Organic chemistry

Author(s):

Rajendra Patil, Jagdish Chavan, Shivnath Patel, Vaishali Shinde, Anil Beldar


Field: Organic chemistry
Type: Research paper
Issue: 2022 Volume 17, no.2
Pages: 101-108
Keywords: Biginelli reaction, acetic acid, acidic charcoal, microwave irradiation.
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Graphical Abstract: A green and efficient method for the multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones and -thiones using acetic acid supported on activated charcoal as a mild acid catalyst in ethanol under both conventional as well as microwave irradiation conditions has been developed. The catalyst system found more efficient under microwave irradiation conditions than conventional conditions with shorter reaction times and excellent yields.


 


Downloads: 126

Author(s):

Dhanraj Kamble, Anil Shankarwar, Yuvraj Sarnikar, Radhakrushna Tigote, Mubarak Shaikh, Pravin Chavan


Field: Organic chemistry
Type: Research paper
Issue: 2022 Volume 17, no.2
Pages: 94-100
Keywords: one pot reaction, substituted benzimidazole, ultrasound irradiation, ZnFe2O4 catalyst, biological activity.
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Graphical Abstract: Herein, an efficient one-pot synthesis is described, of substituted benzimidazole derivatives (3a-j) from a condensation of various o-phenylenediamine (1a-j) aromatic aldehyde (2a-j) using ZnFe2O4 as a nano-catalyst under ultrasonic irradiation conditions. All forms of aldehydes with an electron releasing or electron –withdrawing substituent have a significant yield. The catalyst can easily be recovered after completion of the reaction and reused without affecting its activity. Prepared benzimidazole derivatives showed moderate to good anti-tuberculosis results.


 



Downloads: 83

Author(s):

Silvadas Jesna Das, Mohan Sidharth, Chandroth Kalyad Simi


Field: Organic chemistry
Type: Research paper
Issue: 2022 Volume 17, no.1
Pages: 56-61
Keywords: chitosan, one-pot synthesis, carbodiimide, porous morphology, thermal stability.
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Abstract (PDF)
Graphical Abstract: A facile, one-pot, and solvent-free synthesis was developed to obtain a thermally stable chitosan biopolymer. The bifunctional isocyanate by interaction with chitosan formed urea and urethane bonds between chitosan chains. Subsequently, the designed chemistry facilitated the formation of carbodiimide bonds between chitosan chains via dehydration of the urea bond. The modified chitosan was proved to be superior in thermal properties and could be used as a thermally stable bio-filler. This synthetic methodology is a facile route to achieve improved thermal stability in biopolymers.





Downloads: 122

Author(s):

Aparna Das, Ram Naresh Yadav, Bimal Krishna Banik


Field: Organic chemistry
Type: Short communication
Issue: 2022 Volume 17, no.1
Pages: 62-66
Keywords: β-lactam, loss tangent, microwave, stereospecific, optically active.
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Abstract (PDF)
Graphical Abstract: In this work, the stereospecific synthesis of optically active cis β-lactams under diverse microwave-induced conditions using diverse solvents was reported. The effects of low tanδ values of the solvents are found to be more crucial than solvents with high dipole moments and dielectric constants. The results indicated that for the synthesis of β-lactams solvents with low tanδ and high dipole moment and high dielectric constant are necessary. Best of the knowledge this is the first report that examined the importance of tanδ values of the solvents in β-lactams synthesis.




Downloads: 99

Author(s):

Kabeer Ahmed Shaikh and Uddhav Nivrutti Chaudhar


Field: Organic chemistry
Type: Research paper
Issue: 2020 Volume 15, no.2
Pages: 99-104
Keywords: lanthanum(III) nitrate, xanthene derivative, dimedone, β-naphthol, solvent free condition.
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Abstract (PDF)
Graphical Abstract: The present paper shows that lanthanum(III) nitrate hexahydrate can be used as mild and environment friendly homogeneous catalyst for an efficient one-pot multi-component synthesis of biologically active 1,8-dioxo-octahydroxanthene and 14H-dibenzo[a,j]xanthene derivatives. The solvent free condensation reaction of aromatic aldehydes and dimedone or β-naphthol was carried out at 70-80ºC during 10-30 min. The advantages of this eco-friendly synthesis route are numerous, and include the use of an inexpensive catalyst, high to excellent yield, short reaction time and high catalytic activity that can make this method an interesting alternative to multi-step approaches.


 
 
 


Downloads: 111

Author(s):

Roman Rusnac, Maria Botnaru, Nicanor Barba, Peter Petrenko, Yurii Chumakov, Aurelian Gulea


Field: Organic chemistry
Type: Research paper
Issue: 2020 Volume 15, no.2
Pages: 88-98
Keywords: 1,3-bis(pyridin-2-yl)prop-2-en-1-one, Claisen-Schmidt condensation, intramolecular aldol condensation, Michael addition, substituted cyclohexanol.
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Graphical Abstract: The research is devoted to the study of unexpected products that formed as a result of the condensation reaction between 2-acetylpyridine and 2-formylpyridine under the Claisen-Schmidt reaction conditions. As a result, a sequence of reactions leading to the following compounds has been proposed: 1,3-bis (pyridin-2-yl) prop-2-en-1-one (3); 1,3,5-tri (pyridin-2-yl) pentane-1,5-dione (4); (2,4-dihydroxy-2,4,6-tri(pyridin-2-yl)cyclohexyl)(pyridin-2-yl)methanone (5) and (4-hydroxy-2,4,6-tri(pyridin-2-yl)cyclohexane-1,3-diyl)bis(pyridin-2-ylmethanone) (6) as well as 2-formylpyridine (1) and 2-acetylpyridine (2). The plausible mechanism of these chemical transformations has been proposed. All the obtained compounds demonstrate moderate antimicrobial, antifungal and antioxidant activity.


 


Downloads: 146

Author(s):

Lauro Figueroa, Alejandra Garcimarero, Rolando Garcia, Francisco Diaz, Marcela Rosas, Virginia Mateu, Maria Lopez, Lenin Hau, Tomas Lopez, Abelardo Camacho, Yaritza Borges


Field: Organic chemistry
Type: Research paper
Issue: 2020 Volume 15, no.1
Pages: 75-85
Keywords: bicyclo, steroid, estrone derivative, synthesis, NMR.
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Abstract (PDF)
Graphical Abstract: This study describes the preparation of two bicyclo[3.3.3]nonane-steroid derivatives from either estradiol or estrone using some reactions such as etherification, addition, nucleophilic substitution and cyclization. The chemical structure was evaluated through NMR spectroscopic analysis. The results showed higher yield for 11 compared with 12. It is noteworthy that the reagents used in this investigation are not expensive and do not require special conditions for handling.


 


Downloads: 337

Author(s):

Hajer Hrichi, Nadia Ali Ahmed Elkanzi, Rania Badawy Bakr


Field: Organic chemistry
Type: Research paper
Issue: 2020 Volume 15, no.1
Pages: 86-94
Keywords: heterocycle, β-lactam, quinoxaline, antimicrobial activity, molecular docking.
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Graphical Abstract: A series of novel isolated β-lactams 3a-c and thiazolidinone derivatives 4a-c were successfully synthesized from reactions of new Schiff's bases 2a-c with chloroacetyl chloride and thioglycolic acid. The antimicrobial activity of the obtained compounds was assessed in vitro against gram-positive Staphylococcus aureus and gram-negative Escherichia coli bacteria and Aspergillus flavus and Candida albicans fungi. Furthermore, a molecular docking study was carried out and the results indicated that compounds 3b and 4b displayed comparable binding affinity scores as that of glutamate. These two compounds are promising candidates as antibacterial and antifungal agents that would deserve further investigations.



 


Downloads: 208

Author(s):

Jumina Jumina, Rizky Woro Styaningrum, Dwi Siswanta, Sugeng Triono, Yoga Priastomo, Harizal Harizal, Eti Nurwening Sholikhah, Abdul Karim Zulkarnain


Field: Organic chemistry
Type: Research paper
Issue: 2019 Volume 14, no.2
Pages: 90-96
Keywords: chalcone, photostability, absorbance, sunscreen, broad-spectrum.
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DOI: http://dx.doi.org/10.19261/cjm.2019.624   
 
Abstract (PDF)
Graphical Abstract: Four chalcone derivatives were synthesized and pre-evaluated as broad-spectrum UV protector. Chalcones 1-4 showed a wide range of UV absorbance values and moderate molar absorptivity values. Chalcones 3 and 4 showed better photostability than chalcones 1 and 2 because the lowering of their absorbance was smaller and slower under UVB irradiation. A combination of the spectra of chalcone derivatives 1-4 indicated that a formulation containing all four will provide a broad-spectrum sunscreen protecting the skin from UVA and UVB. 


 


Downloads: 212

Author(s):

Nadia Ali Ahmed Elkanzi, Amira Atef Ghoneim, Hajer Hrichi


Field: Organic chemistry
Type: Research paper
Issue: 2019 Volume 14, no.2
Pages: 105-116
Keywords: pyrazole, imidazole, pyrimidine, indol, antimicrobial activity.
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DOI: http://dx.doi.org/10.19261/cjm.2019.638   

Abstract (PDF)
Graphical Abstract: In this study, novel pyrazole, imidazole, pyrimidine derivatives bearing imidazo[4,5-b]indol moiety were successfully synthesized and their chemical structures were identified and confirmed by different spectral techniques. All the synthesized compounds were tested against four bacterial strains (Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa) and two fungi (Aspergillus flavus and Candida albicans). The obtained results show that the synthesized compounds could find fruitful applications as antibacterial and antifungal agents in pharmaceutical chemistry.


 


Downloads: 190