Natural product chemistry and synthesis

PHARMACOLOGICAL AND MEDICINAL CHEMISTRY ASPECTS OF CANNABIS COMPOUNDS

Author(s):

T. Cotelea

Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2011 Volume 6, no.2
Pages: 16-18

Keywords: Cannabis compounds, metabolism, pharmacological action, phisico-chemical analysis.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2011.06(2).04

Graphical Abstract: The current communication includes a general overview of the scientific interest and medicianl chemistry aspects of Cannabis compounds. It relates to metabolism, pharmacological action and phisico-chemical analysis of these compounds, as well as of some isomers differing in spatial arrangement of functional groups.

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EXPLORING THE CHEMISTRY OF MARINE OPISTHOBRANCHS: RECENT RESULTS

Author(s):

Margherita Gavagnin

Field: Natural product chemistry and synthesis
Type: Invited paper
Issue: 2011 Volume 6, no.2
Pages: 19-23

Keywords: natural product chemistry, marine opisthobranch molluscs, bioactive molecules.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2011.06(2).05

Graphical Abstract: The current communication is an extended abstract of the presentation delivered on the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, held in the Institute of Chemistry, Academy of Sciences of Moldova on 30th September. An overview of the recent studies conducted by our group on opisthobranch molluscs from distinct geographical areas is briefly presented.

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SYNTHETIC APPROACHES TO POLIFUNCTIONALIZED PERHYDRINDANES

Author(s):

Veaceslav Kulciţki

Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2011 Volume 6, no.2
Pages: 24-26

Keywords: natural product chemistry, diterpenoids.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2011.06(2).06

Graphical Abstract: The current communication represents an extended abstract of the presentation delivered on the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, held in the Institute of Chemistry, Academy of Sciences of Moldova on 31 September. An overview of the synthetic methods oriented to the synthesis of functionalized terpenic perhydrindanes is provided. Different synthetic strategies are considered, including those based on biomimetic approach. The array of obtained new structures can serve as leads in structure-activity studies as well as useful building blocks towards other perhydrindanes.

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SYNTHETIC STRATEGY FOR THE PREPARATION OF BIOACTIVE GALACTOGLYCEROLIPIDS

Author(s):

Emiliano Manzo, Maria Letizia Ciavatta, Dario Pagano and Angelo Fontana

Field: Natural product chemistry and synthesis
Type: Invited paper
Issue: 2011 Volume 6, no.2
Pages: 27-29

Keywords: Glycolipids, bio-medical applications, galactosyldiacylglycerols.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2011.06(2).07

Graphical Abstract: The current communication represents an extended abstract of the presentation delivered on the joint Moldo-Italian seminar “New frontiers in natural product chemistry”, held in the Institute of Chemistry, Academy of Sciences of Moldova on 30 September. A simple and efficient strategy for the synthesis of galactoglycerolipids is provided.

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TARGET-ORIENTED SYNTHESIS OF SOME TERPENOIDS OF MARINE ORIGIN

Author(s):

Nicon Ungur

Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2011 Volume 6, no.2
Pages: 30-35

Keywords: marine natural products, terpenoids; glycerol; scalaranes, cheilanthanes, sesterterpenoids, cyclizations, superacids, rearrangements, synthesis.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2011.06(2).08

Graphical Abstract: The paper presents an outline of the synthesis of some natural terpenoids of marine origine having diverse carbocyclic skeletons: labdanic, isocopalic, scalaranic, cheilanthanic, drimanic, sacculatanic. Schemes – 6, figures - 2. Bibliographic references – 35.

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SYNTHESIS AND PHOTOOXYGENATION OF THE METHYL ESTER OF 11-HOMODRIM-6,8(9)-DIENE-12-OIC ACID

Author(s):

Biriiac Andrei

Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2011 Volume 6, no.2
Pages: 79-83

Keywords: homodrimanes, synthesis, photooxygenation.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2011.06(2).17

Graphical Abstract:

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ON THE PECULIARITIES OF THE RING CONTRACTION REACTIONS OF HOMODRIMANES VIA ACID MEDIATED EPOXIDE REARRANGEMENT

Author(s):

Veaceslav Kulciţki, Tatiana Sîrbu, Nicon Ungur

Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2011 Volume 6, no.1
Pages: 110-112

Keywords: terpenoids, homodrimane, epoxide, rearrangement, hydrindane.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2011.06(1).02

Graphical Abstract: A selective rearrangement of a epoxy-homodrimanic substrate is described. Using fluorosulfonic acid at low temperature leads by ring contraction to a perhydrindanic structure. On the contrary, using boron trifluoride-diethyl ether at r.t. selectively brings about angular methyl migration.

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OCCURRENCE AND CHEMISTRY OF DIHYDROXYFUMARIC ACID

Author(s):

N. Secara, Gh. Duca, L. Vlad, F. Macaev

Field: Natural product chemistry and synthesis
Type: Review
Issue: 2011 Volume 6, no.1
Pages: 29-44

Keywords: dihydroxyfumaric acid, ﬂuorescent sensors, molecular clips, coordination polymers.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2011.06(1).14

Graphical Abstract:

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SYNTHESIS OF NITROGEN-CONTAINING COMPOUNDS FROM HIGHER TERPENOIDS

Author(s):

Aculina Aricu

Field: Natural product chemistry and synthesis
Type: Review
Issue: 2011 Volume 6, no.1
Pages: 10-28

Keywords: synthesis, nitrogen-containing compounds, terpenoids, Beckmann rearrangement.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2011.06(1).15

Graphical Abstract: The presence of nitrogen in the molecule is usually accompanied either by the appearance of a new activity or the intensification of original activity characteristic for the native terpenoids. This maintains alive the scientific interest in the synthesis of such compounds. The present communication put into discussion the recently elaborated methods for preparation of the nitrogen-containing terpenic compounds.

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ON SOME PECULIARITIES OF ETHYL 5-HYDROXY-1,2-DIMETHYL-1H-3-INDOLECARBOXYLATE SYNTHESIS

Author(s):

Felix Shepel, Diana Shepel, Fliur Macaev

Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2009 Volume 4, no.2
Pages: 116-117

Keywords: derivatives of 5-oxindole, cardio-vascular remedies.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2009.04(2).01

Graphical Abstract: It has been conducted increase the yield up to 63% of ethyl 5-hydroxy-1,2-dimethyl-1H-3-indolecarboxylate via interaction of p-benzoquinone with N-methyl-b-aminocrotone ether in mixture of glacial acetic acid/ethyl acetate.

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