Natural product chemistry and synthesis

STEROIDAL GLYCOSIDES FROM THE SEEDS OF HYOSCYAMUS NIGER L. AND THEIR ANTIFUNGAL ACTIVITY

Author(s):

Irina Lunga, Pavel Chintea, Stepan Shvets, Anna Favelb and Cosimo Pizza

Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2007 Volume 2, no.1
Pages: 108-113

Keywords: Hyoscyamus niger L., steroidal glycosides, antifungal activity.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2007.02(1).05

Graphical Abstract: Phytochemical analysis of the seeds of Hyocyamus niger L. (Solonaceae) resulted in the isolation of six steroidal glycosides, two furostanol (1, 2) and four spirostanol saponins (3, 4, 5, 6), which were found in this plant for the first time. The structures of these compounds were determined by detailed analysis of their spectral data, including two-dimensional NMR spectroscopy and MS spectroscopy. The antifungal activity of a crude steroidal glycoside extract, fractions of spirostanoles and individual glicosides was investigated in vitro against a panel of human pathogenic fungi, yeasts as well as dermatophytes and filamentous species.

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INVESTIGATION OF GRAPE SEED PROANTHOCYANIDINS. ACHIEVEMENTS AND PERSPECTIVES

Author(s):

V. Kulciţki, P. F. Vlad, Gh. Duca, T. Lupaşcu

Field: Natural product chemistry and synthesis
Type: Review
Issue: 2007 Volume 2, no.1
Pages: 36-50

Keywords: polyphenols, proanthocyanidins, grape seeds, chromatography, MS, NMR.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2007.02(1).16

Graphical Abstract:

The present paper provides an account of the basic technuques employed in the investigation of the grape seeds proanthocyanidins (condensed tannins). The importance and biological activity properties of these compounds are considered briefly in the introductory part, while isolation and structural investigation of grape seeds proanthocyanidins represent the basic part of the review. The references cover mostly the recent publications related to implementation of modern techniques of investigation, like high performance liquid chromatography (HPLC) and mass spectrometry (MS).

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THREE SPIROSTANOL GLYCOSIDES FROM THE SEEDS OF HYOSCYAMUS NIGER L.

Author(s):

Irina Lunga, Pavel Kintia, Stepan Shvets, Carla Bassarelo, Cosimo Pizza and Sonia Piacente

Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2006 Volume 1, no.1
Pages: 100-103

Keywords: steroidal glycoside, NMR analysis, Hyoscyamus.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2006.01(1).02

Graphical Abstract: Three steroidal glycosides of spirostane series have been isolated from the seeds of Hyoscyamus niger L.(Solanaceae). Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods including one-dimensional, two-dimensional NMR and MS analysis. In the genus Hyoscyamus the given compounds have been found out for the first time.

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ELECTROPHILIC CYCLIZATION OF DITERPENOIDS

Author(s):

Veaceslav Kulciţki, Marina Grinco, Pavel Vlad, Nicon Ungur

Field: Natural product chemistry and synthesis
Type: Review
Issue: 2006 Volume 1, no.1
Pages: 22-35

Keywords: isoprenoids, diterpenoids, electrophilic cyclization, superacids.
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Abstract (JPEG)

DOI: dx.doi.org/10.19261/cjm.2006.01(1).07

Graphical Abstract: A review of diterpenoid cyclization initiated by electrophilic reagents is provided. Conventional protonic and Lewis acids are examined along with superacids as initiators of cyclization cascade. An emphasis is placed on the use of cyclization reactions as a tool for the synthesis of compounds with potential practical utility. The review contains 74 references.

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Chemistry Journal of Moldova