Chemistry Journal of Moldova

Natural product chemistry and synthesis

Author(s):

Hadjira Naoui, Mohamed Benalia, Soumaya Hachani, Amar Djeridane, Ziyad Ben Ahmed, Veronique Seidel, Mohamed Yousfi


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2023 Volume 18, no.1
Pages: 92-101
Keywords: oil extract, fatty acid, tocopherol, sterol, antioxidant activity.
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https://doi.org/10.19261/cjm.2023.1029

Abstract (PDF)
Graphical Abstract:
Samples of oils from seven types of Ficus carica L. fruits from Algeria were investigatedwith the aim to assess the chemical characteristics, quantifying sterols and tocopherols, and to analyse the fatty acids profiles using gas chromatography, and evaluation of antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl method and total antioxidant activity using phosphomolybdenum methods. The results showed that the major unsaturated fatty acids of different lipid classes were linoleic (11.70-34.74%) and linolenic (1.15-35.27%), the main saturated fatty acids was palmitic. Aditionally, it was demonstrated for the first time that the studied figs oils possessed good antioxidant activity which may be associated with their alleged health benefits. 








Downloads: 89

Author(s):

Svetlana Blaja, Lidia Lungu, Alexandru Ciocarlan, Nicoleta Vornicu, Aculina Aricu


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2023 Volume 18, no.1
Pages: 86-91
Keywords: (+)-sclareolide, tetranorlabdane compound, 1,3,4-thiadiazole, thiosemicarbazone, antimicrobial activity.
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Abstract (PDF)
Graphical Abstract:
The study describes the synthesis of novel tetranorlabdane compounds bearing 1,3,4-thiadiazole units and intermediary tetranorlabdane compounds with thiosemicarbazone fragment. The structures of the synthesized compounds were confirmed using IR and 1H, 13C, and 15N NMR spectroscopy. The in vitro antifungal and antibacterial activities of the tetranorlabdane compounds with thiosemicarbazone and 1,3,4-thiadiazole units have been evaluated. One of the tested compounds has an excellent activity against five strains of fungi and two species of bacteria at minimum inhibitory concentration values of 0.125 and 2.5 µg/mL, respectively.  


 


Downloads: 127

Author(s):

Alexandru Ciocarlan


Field: Natural product chemistry and synthesis
Type: Review
Issue: 2022 Volume 17, no.2
Pages: 19-34
Keywords: (-)-sclareol, norlabdane-heterocyclic compound, antimicrobial activity, biological activity.
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Graphical Abstract: This review relates to chemistry of the well-known biologically active natural labdane diterpenoid (-)-sclareol easily available from Clary sage (Salvia sclarea L.). It is mainly used in industry, especially for synthesis of fragrance compounds and natural analogs. The paper covers achievements on the synthesis, structure determination and biological activity of molecular hybrid compounds bearing hydrazide and thiosemicarbazone fragments or diazine, 1,2,4-triazole, carbazole, 1,3-thiazole, 1,3,4-oxadiazole, 1,3,4-thiadiazole units prepared based on it. 


 



Downloads: 63

Author(s):

Lyubov Patrylak, Stepan Zubenko, Serhyi Konovalov, Anzhela Yakovenko, Volodymyr Povazhnyi, Oleksandra Pertko, Yulia Voloshyna, Oleksandr Melnychuk, Mykhailo Filonenko


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2022 Volume 17, no.2
Pages: 84-93
Keywords: kaolin, zeolite, limonene isomerization, terpinolene yield.
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Abstract (PDF)
Graphical Abstract:
The aim of the work was to study the isomerization of limonene on zeolite-containing biporous acid catalysts based on kaolin (from Ukraine). Results of this study show that at 160°C, the maximum isomer yield was 60–65% with an 80–90% conversion. The studied samples do not have a significant accumulation of carbonaceous deposits because limonene has high solubility, which helps to remove intermediate products of transformation from the surface of the samples. 


 


Downloads: 56

Author(s):

Alexandru Ciocarlan, Lucian Lupascu, Aculina Aricu, Ion Dragalin, Nina Ciocarlan, Inga Zinicovscaia, Valerina Slanina, Nikita Yushin


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2021 Volume 16, no.2
Pages: 83-90
Keywords: chemical composition, essential oil, ethanolic extract, antimicrobial activity, Corymbflower tansy.
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Abstract (PDF)
Graphical Abstract:
The GC-MS analysis of the essential oil from Tanacetum corymbosum revealed the presence of 38 compounds, including terpenes - germacrene D, (Z)-β-farnesene, g-elemene, β-caryophyllene, aliphatic - palmitic and linoleic fatty acids, fatty alcohol n-octadecanol, higher alkane n-heneicosane as the major constituents. The in vitro antimicrobial assessment of the ethanolic extract showed promising antibacterial/antifungal activities against five Gram-(+), Gram-(-) and phytopathogenic bacteria species and two fungi strains. The data obtained in this study may be useful both for researchers and for producers interested in new or less studied species of medicinal plants in healthcare and their biological activities.


 


Downloads: 113

Author(s):

Nina Djapic


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2021 Volume 16, no.2
Pages: 76-82
Keywords: chlorophyll catabolite, structure, nuclear magnetic resonance, Atropa belladonna, Solanum tuberosum.
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Graphical Abstract: The study described the isolation of β-D-galactopyranoside seco-phytoporphyrin from Atropa belladonna and Solanum tuberosum yellow leaves. Column chromatography was applied for its isolation. The UV-Vis, mass spectrometry and NMR spectroscopy were used for the structure confirmation. The results demonstrate that the two plants that the same chlorophyll catabolite structure. 


 


Downloads: 62

Author(s):

Wan Mohd Nuzul Hakimi Wan Salleh, Muhammad Helmi Nadri, Shamsul Khamis


Field: Natural product chemistry and synthesis
Type: Short communication
Issue: 2021 Volume 16, no.2
Pages: 112-116
Keywords: essential oil, hydrodistillation, lipoxygenase, Alstonia angustiloba, Apocynaceae.
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Abstract (PDF)
Graphical Abstract:
This study was aimed to investigate the chemica l compositions and lipoxygenase inhibitory activity of the essential oil from Alstonia angustiloba growing in Malaysia. The essential oils were obtained by hydrodistillation and fully characterized by gas chromatography and gas chromatography-mass spectrometry. Analysis of the A. angustiloba essential oil resulted in the identification of twenty-five chemical components, attributed 90.8% of the total oil. The most abundant components of A. angustiloba oil were linalool (21.2%), 1,8-cineole (16.8%), α-terpineol (9.5%), terpinene-4-ol (8.5%), β-caryophyllene (6.2%), and caryophyllene oxide (5.2%). The essential oil displayed moderate activity towards lipoxygenase activity with IC50 value of 45.8 μg/mL. 



 


Downloads: 72

Author(s):

Aculina Aricu


Field: Natural product chemistry and synthesis
Type: Invited paper
Issue: 2021 Volume 16, no.1
Pages: 8-29
Keywords: labdane diterpenoid, tetrahydrofuran, ozonolytic method, superacidic cyclisation, structure-ambra odour relationship.
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Abstract (PDF)
Graphical Abstract: The purpose of this paper is to put forward concisely some of the most valuable scientific contributions of academician Pavel Vlad and his disciples to the field of natural product chemistry of terpenoids. Under the guidance and with direct contribution of academician Pavel Vlad, new approaches to determining the absolute configuration of a series of labdanic diterpenoids and of converting them into bi-, tri- and tetra- cyclic compounds have been designed. Novel universal methods for synthesizing tetrahydrofurans from 1,4-glycols, olefins from tertiary alcoholic acetates, as well as dienones by means of photodehydrogenation of unsaturated cyclic ketons have been developed by academician Pavel Vlad.


Downloads: 253

Author(s):

Roman Ivannikov, Iryna Laguta, Viktor Anishchenko, Iryna Skorochod, Pavlo Kuzema, Oksana Stavinskaya, Ivan Parnikoza, Oksana Poronnik, Ganna Myryuta, Viktor Kunakh


Field: Natural product chemistry and synthesis
Type: Research paper
Issue: 2021 Volume 16, no.1
Pages: 105-114
Keywords: phenolic acid, flavonoid, antiradical activity, plant extract, Deschampsia antarctica.
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Graphical Abstract: The work was aimed at studying the phytochemicals available in D. antarctica plants from various sites on Antarctic Islands, introducing the plants into in vitro culture and comparing the extracts from the plants grown in situ and in vitro. All the extracts were found to contain high amount of phenols, with luteolin and hydroxybenzoic acids derivatives being the main phytochemicals in the extracts from the plants grown in situ and in vitro. Being diluted by 10 times, the extracts scavenged 50÷90% of DPPH• radicals, 20÷40% of NO• radicals and 40÷60% of OH• radicals. Despite the differences in composition, extracts from the plants grown in situ and in vitro showed similar radical scavenging activity.


 


Downloads: 252

Author(s):

Alexandru Ciocarlan


Field: Natural product chemistry and synthesis
Type: Review
Issue: 2021 Volume 16, no.1
Pages: 30-45
Keywords: (+)-larixol, larixyl acetate, synthesis, chemical composition, biological activity.
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Abstract (PDF)
Graphical Abstract: (+)-Larixol is a well-known labdane-type diterpenoid widely used in organic synthesis. The present review covers the (+)-larixol based chemical transformations, the results of phytochemical analysis of new (+)-larixol containing species, as well as recent data on biological activity of (+)-larixol and practical applications where it is mentioned.


 


Downloads: 180